NSAIDs (NSAIDs) are a group of drugs that combine an analgesic, antipyretic and anti-inflammatory effects.These formulations are aimed at reducing pain, fever and inflammation.The best-known representatives of this group are aspirin, diclofenac and ibuprofen.Use of NSAIDs provided in the case of chronic and acute diseases which are accompanied by inflammation and pain.To date, conducted a study aimed at identifying opportunities to influence colorectal cancer, as well as the study of their effectiveness in the treatment of cardiovascular diseases.Nonsteroidal anti-inflammatory drugs - what is it and how they work?NSAIDs are among the most important "symptomatic" of drugs, particularly in the treatment of rheumatic diseases.
NSAIDs NSAIDs may be prescribed for the treatment of:
- rheumatoid arthritis;
- inflammatory arthropathy (ankylosing spondylitis, psoriatic arthritis, Reiter's syndrome);
- bone metastases with pain;
- headache and migrain
- post-operative pain;
- pain mild or moderate severity in the presence of inflammatory changes in the event of an injury;
- renal colic.
On chemical structure of NSAIDs are:
- pyrazolone derivatives;
- salicylic acid derivatives;
- anthranilic acid derivatives;
- propionic acid derivatives;
- acetic acid derivatives;
- oxicam derivatives;
- isonicotinic acid derivatives;
- coxibs derivatives;
- derived from other chemical groups;
- combination therapy.
Mechanism of action distinguish selective inhibitors of COX-1, non-selective COX-1 and COX-2 drugs, mainly influencing the COX-2, highly selective COX-2 inhibitors.
All new nonsteroidal drugs have a number of common pharmaceutical and chemical properties.They are weak organic acids, and therefore is marked good absorption in the gastrointestinal tract.Hypoalbuminemia leads to the fact that increased serum concentrations of free drug than can be attributed to increased toxicity.Marked variation in the duration of half-life of NSAIDs widely.NSAIDs can be conditionally divided into short-lived (less than 6 hours) and dlitelnozhivuschie (over 6 hours).The development of toxic reactions and therapeutic response is determined by many factors, including the time it takes to make it reached the equilibrium state of the drug in plasma and it is roughly 3-5 times the duration of the five half-lives.Not traced the clear link half-life of NSAIDs in the plasma and its clinical efficacy.The reason is that the short-lived drugs are stored in the area of inflammation, for example, a joint cavity, for a long time and at high concentrations.So often on the effectiveness of short twice-daily drug is not inferior to many times.
NSAIDs NSAIDs are not recommended during pregnancy, especially during the third trimester.There may be induced lesions of the gastrointestinal tract in the case of:
- elderly (especially after 60 years);
- high doses of NSAIDs;
- associated with NSAID gastrointestinal lesions or duodenal ulcer history;
- simultaneously receiving anticoagulants, glucocorticoids or more NSAIDs.
risk factors of cardiovascular and renal side effects of NSAIDs include the presence of:
- congestive heart failure;
- cirrhosis of the liver;